Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure - Sabbah, Hani N.; Gupta, Ramesh C.; Kohli, Smita; Wang, Mengjun; Hachem, Souheila; Zhang, Kefei (Circulation. Heart failure, 2016)
Keywords: Animals; Biomarkers - blood; C-Reactive Protein - metabolism; Disease Models, Animal; Dogs; Energy Metabolism - drug effects; Heart Failure - blood; Heart Failure - drug therapy; Heart Failure - physiopathology; Infusions, Intravenous; Injections, Subcutaneous; Membrane Potential, Mitochondrial - drug effects; Mitochondria, Heart - drug effects; Mitochondria, Heart - metabolism; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Natriuretic Peptide, Brain - blood; Oligopeptides - administration & dosage; Oligopeptides - pharmacology; Peptide Fragments - blood; Reactive Oxygen Species - metabolism; Recovery of Function; Stroke Volume - drug effects; Time Factors; Tumor Necrosis Factor-alpha - blood; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - drug therapy; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left - drug effects; heart failure; myocardial energetics; cardiolipin; mitochondria; ventricular function