Matrix metalloproteinases and their tissue inhibitors in the lesions of cardiac and pulmonary sarcoidosis: An immunohistochemical study

• Published in: Human pathology Vol. 33; no. 12; pp. 1158 - 1164
• Main Authors: González, A.Adrián, Segura, Ana M., Horiba, Koji, Qian, Sujuan, Yu, Zu-Xi, Stetler-Stevenson, William, Willerson, James T., McAllister, Hugh A., Ferrans, Victor J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2002; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Cardiomyopathies - enzymology; Cardiomyopathies - pathology; Collagen Type IV - analysis; Female; heart disease; Humans; Immunoenzyme Techniques; Immunohistochemistry; lung disease; Male; Matrix Metalloproteinase 1 - analysis; Matrix Metalloproteinase 2 - analysis; Matrix Metalloproteinase 3 - analysis; Matrix Metalloproteinase 7 - analysis; Matrix Metalloproteinase 9 - analysis; Matrix Metalloproteinases - analysis; Medical sciences; metalloproteinases; Microscopy, Confocal; Middle Aged; sarcoidosis; Sarcoidosis - enzymology; Sarcoidosis - pathology; Sarcoidosis, Pulmonary - enzymology; Sarcoidosis, Pulmonary - pathology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Tissue Inhibitor of Metalloproteinase-1 - analysis; Tissue Inhibitor of Metalloproteinase-2 - analysis; Tissue Inhibitor of Metalloproteinases - analysis; MMP; ABC; FITC; heart disease; metalloproteinases; sarcoidosis; lung disease; immunohistochemistry; TIMP; Heart; Immunohistochemistry; Pathogenesis; Lung; Cardiovascular disease; Metalloendopeptidases; Heart disease; Systemic disease; Interstitial; Interstitial collagenase; Human; Lung disease; Stromelysin 1; Sarcoidosis; Respiratory disease; Enzyme; Enzyme inhibitor; Gelatinase B; Gelatinase A; Pathology; Peptidases; Fibrosis; Hydrolases; Matrilysin

The pathogenesis of the tissue damage and fibrosis in sarcoidosis is poorly understood. The matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) must be considered in this regard, because they control the lysis of connective tissue components. Immunohistochemical studies (peroxidase...