5-Fluorouracil Impairs Transmission of Acetylcholine in the Hippocampus and Induces Cognitive Impairments in Mice

• Published in: Journal of integrative neuroscience Vol. 24; no. 4; pp. 26903 - 10
• Main Authors: Huang, Xiwen, Peng, Shunqing, Lan, Yongquan, Chen, Wenjun, Wu, Jianlin
• Format: Journal Article
• Language: English
• Published: Singapore IMR Press 18.04.2025
• Subjects: 5-Fluorouracil; acetylcholine; Acetylcholine - metabolism; Acetylcholinesterase; Animals; Antimetabolites, Antineoplastic - toxicity; Biocytin; Cancer therapies; Chemotherapy; Chemotherapy-Related Cognitive Impairment - etiology; Chemotherapy-Related Cognitive Impairment - metabolism; Chemotherapy-Related Cognitive Impairment - physiopathology; cholinergic neurons; Cholinergic Neurons - drug effects; Cholinergic Neurons - metabolism; Cholinergics; Cholinesterase inhibitors; Cholinesterase Inhibitors - pharmacology; Cognitive ability; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - metabolism; cognitive impairments; Disease Models, Animal; Donepezil; Donepezil - pharmacology; Fluorouracil - toxicity; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Male; medial septum; Medical research; Mice; Mice, Inbred C57BL; Microdialysis; Neurons; Structural integrity; Synaptic Transmission - drug effects; Guangzhou China; China; 5-fluorouracil; cholinergic neurons; acetylcholine; medial septum; cognitive impairments

Background: Chemotherapy-induced cognitive impairments are a significant adverse sequela of cancer treatment. The potential mechanism of chemotherapy-induced cognitive impairments remains elusive. The present study evaluated the impact of a commonly utilized chemotherapy agent, 5-fluorouracil (5-FU)...