5-Fluorouracil Impairs Transmission of Acetylcholine in the Hippocampus and Induces Cognitive Impairments in Mice - Huang, Xiwen; Peng, Shunqing; Lan, Yongquan; Chen, Wenjun; Wu, Jianlin (Journal of integrative neuroscience, 2025)
Keywords: 5-Fluorouracil; acetylcholine; Acetylcholine - metabolism; Acetylcholinesterase; Animals; Antimetabolites, Antineoplastic - toxicity; Biocytin; Cancer therapies; Chemotherapy; Chemotherapy-Related Cognitive Impairment - etiology; Chemotherapy-Related Cognitive Impairment - metabolism; Chemotherapy-Related Cognitive Impairment - physiopathology; cholinergic neurons; Cholinergic Neurons - drug effects; Cholinergic Neurons - metabolism; Cholinergics; Cholinesterase inhibitors; Cholinesterase Inhibitors - pharmacology; Cognitive ability; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - metabolism; cognitive impairments; Disease Models, Animal; Donepezil; Donepezil - pharmacology; Fluorouracil - toxicity; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Male; medial septum; Medical research; Mice; Mice, Inbred C57BL; Microdialysis; Neurons; Structural integrity; Synaptic Transmission - drug effects; Guangzhou China; China; 5-fluorouracil; cholinergic neurons; acetylcholine; medial septum; cognitive impairments