The Role of Bacillithiol in Gram-Positive Firmicutes

• Published in: Antioxidants & redox signaling Vol. 28; no. 6; p. 445
• Main Authors: Chandrangsu, Pete, Loi, Vu Van, Antelmann, Haike, Helmann, John D
• Format: Journal Article
• Language: English
• Published: United States 20.02.2018
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - metabolism; Bacillus subtilis - enzymology; Bacillus subtilis - metabolism; Cysteine - analogs & derivatives; Cysteine - chemistry; Cysteine - metabolism; Firmicutes - enzymology; Firmicutes - metabolism; Glucosamine - analogs & derivatives; Glucosamine - chemistry; Glucosamine - metabolism; Oxidative Stress; Staphylococcus aureus - enzymology; Staphylococcus aureus - metabolism; Sulfhydryl Compounds - metabolism; Sulfur - metabolism; methylglyoxal; bacilliredoxin; Bacillus subtilis; metal homeostasis; BSH biosynthesis; Staphylococcus aureus; S-bacillithiolation; bacillithiol
• ISSN: 1557-7716
• DOI: 10.1089/ars.2017.7057

Since the discovery and structural characterization of bacillithiol (BSH), the biochemical functions of BSH-biosynthesis enzymes (BshA/B/C) and BSH-dependent detoxification enzymes (FosB, Bst, GlxA/B) have been explored in Bacillus and Staphylococcus species. It was shown that BSH plays an important...