Synthesis of ethyl-(3 R,5 S)-dihydroxy-6-benzyloxyhexanoates via diastereo- and enantioselective microbial reduction: Cloning and expression of ketoreductase III from Acinetobacter sp. SC 13874
Previously we have demonstrated the reduction of ethyl and t-butyl diketoesters 1 to the corresponding syn-(3 R,5 S)-dihydroxy esters 2a by Acinetobacter sp. 13874. The syn-(3 R,5 S)-dihydroxy ester 2a was obtained with an enantiomeric excess (e.e.) of 99% and a diastereomeric excess (de) of 63%. In...
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Published in | Enzyme and microbial technology Vol. 43; no. 7; pp. 544 - 549 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Inc
10.12.2008
Elsevier |
Subjects | |
Online Access | Get full text |
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