Urinary bisphenol-A levels in children with type 1 diabetes mellitus

• Published in: Journal of Pediatric Endocrinology & Metabolism Vol. 31; no. 8; pp. 829 - 836
• Main Authors: İnce, Tolga, Balcı, Aylin, Yalçın, Siddika Songül, Özkemahlı, Gizem, Erkekoglu, Pinar, Kocer-Gumusel, Belma, Yurdakök, Kadriye
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 28.08.2018; Walter de Gruyter GmbH
• Subjects: Adolescent; Benzhydryl Compounds - urine; Biomarkers - urine; Birth weight; bisphenol-A; Case-Control Studies; Child; Child, Preschool; children; Diabetes; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 1 - urine; endocrine disrupting chemicals; Female; Follow-Up Studies; Free Radical Scavengers - urine; Humans; Male; Phenols - urine; Prenatal exposure; Prognosis; Turkey - epidemiology; type 1 diabetes mellitus; type 1 diabetes mellitus; children; endocrine disrupting chemicals; bisphenol-A
• DOI: 10.1515/jpem-2018-0141
• ISSN: 0334-018X

Bisphenol-A (BPA) is one of the most abundantly produced chemicals globally. Concerns have been raised about BPA's possible role in the pathogenesis of type 1 diabetes mellitus (T1DM). The main aim of the current study was to evaluate the possible association between BPA exposure and T1DM. The second aim was to investigate children's possible BPA exposure routes in Turkey. A total of 100 children aged between 5 and 18 years including 50 children with T1DM and 50 healthy children were included. Urinary BPA levels of all children were measured using high-performance liquid chromatography. Mothers of children enrolled in the study were also requested to complete a survey that included questions on the sociodemographic characteristics, medical history and possible BPA exposure routes of their children. In the T1DM group, urinary BPA levels were slightly higher compared to the control group, but this difference was not significant (p=0.510). However, there was an inverse relationship between current urinary BPA levels and birth weight. It was found that the use of plastic kettles and the consumption of dairy products in plastic boxes significantly increased the urinary BPA concentrations in all subjects. Although there was no significant association between urinary BPA levels and T1DM, we found an inverse relationship between current urinary BPA levels and birth weight. This finding might be important for prenatal exposure, and further prospective research must be conducted. Also, the use of plastic kettles, which has not been mentioned much in the literature before, was found to be an important exposure route for BPA.