RET Kinase-Regulated MicroRNA-153-3p Improves Therapeutic Efficacy in Medullary Thyroid Carcinoma

• Published in: Thyroid (New York, N.Y.) Vol. 29; no. 6; p. 830
• Main Authors: Joo, Lauren Jin Suk, Weiss, Jocelyn, Gill, Anthony J, Clifton-Bligh, Roderick, Brahmbhatt, Himanshu, MacDiarmid, Jennifer A, Gild, Matti L, Robinson, Bruce G, Zhao, Jing Ting, Sidhu, Stan B
• Format: Journal Article
• Language: English
• Published: United States 01.06.2019
• Subjects: microRNAs; tyrosine kinase inhibitors; tumor suppressors; cabozantinib resistance; targeted intravenous delivery; nanocells

Medullary thyroid carcinoma (MTC) presents a disproportionate number of thyroid cancer deaths due to limited treatment options beyond surgery. Gain-of-function mutations of the human REarranged during Transfection ( ) proto-oncogene have been well-established as the key driver of MTC tumorigenesis....