Cellular senescence in tumor immune escape: Mechanisms, implications, and therapeutic potential

• Published in: Critical reviews in oncology/hematology Vol. 208; p. 104628
• Main Authors: You, Li, Wu, Qinghua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2025
• Subjects: Animals; Autophagy; Autophagy - immunology; Cellular senescence; Cellular Senescence - immunology; Humans; Immunotherapy; Immunotherapy - methods; Inflammation; Neoplasms - immunology; Neoplasms - pathology; Neoplasms - therapy; Tumor Escape - immunology; Tumor immune escape; Tumor Microenvironment - immunology; Inflammation; Tumor immune escape; Autophagy; Immunotherapy; Cellular senescence

Cellular senescence, a hallmark of aging, has emerged as a captivating area of research in tumor immunology with profound implications for cancer prevention and treatment. In the tumor microenvironment, senescent cells exhibit a dual role, simultaneously hindering tumor development through collabora...