Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting

• Published in: EMBO reports Vol. 25; no. 7; pp. 2878 - 2895
• Main Authors: Steinhoff, Julia S, Wagner, Carina, Dähnhardt, Henriette E, Košić, Kristina, Meng, Yueming, Taschler, Ulrike, Pajed, Laura, Yang, Na, Wulff, Sascha, Kiefer, Marie F, Petricek, Konstantin M, Flores, Roberto E, Li, Chen, Dittrich, Sarah, Sommerfeld, Manuela, Guillou, Hervé, Henze, Andrea, Raila, Jens, Wowro, Sylvia J, Schoiswohl, Gabriele, Lass, Achim, Schupp, Michael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.05.2024; EMBO Press
• Subjects: Adipocytes; Adipose Tissue; Animals; Biochemistry, Molecular Biology; Biomedical and Life Sciences; EMBO21; Fasting; Food and Nutrition; Life Sciences; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Retinol-Binding Proteins, Plasma; Sterol Esterase; Vitamin A; HSL; Vitamin A; RBP4; Fasting; Retinol

Vitamin A (retinol) is distributed via the blood bound to its specific carrier protein, retinol-binding protein 4 (RBP4). Retinol-loaded RBP4 is secreted into the circulation exclusively from hepatocytes, thereby mobilizing hepatic retinoid stores that represent the major vitamin A reserves in the b...