Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children

• Published in: Journal of Pediatric Endocrinology & Metabolism Vol. 30; no. 5; pp. 525 - 530
• Main Authors: Araki, Shunsuke, Yamamoto, Yukiyo, Saito, Reiko, Kawakita, Aoi, Eguchi, Mami, Goto, Motohide, Kubo, Kazuyasu, Kawagoe, Rinko, Kawada, Yasusada, Kusuhara, Koichi
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.05.2017; Walter de Gruyter GmbH
• Subjects: Adolescent; Biomarkers - blood; Blood Glucose - analysis; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Child; child and adolescents; Child, Preschool; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Female; Glucose; glucose tolerance test; Glucose Tolerance Test - adverse effects; Humans; Hyperglycemia; Hyperglycemia - etiology; insulin; Insulin - blood; Male; Plasma; platelets; glucose tolerance test; brain-derived neurotrophic factor; insulin; child and adolescents; platelets

Little is known regarding the relationships among circulating brain-derived neurotrophic factor (BDNF) levels and glucose or insulin in children and adolescents. The objective of this study was to investigate whether circulating BDNF levels would change during the oral glucose tolerance test (OGTT)....