Inter-Observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma

• Published in: Thyroid (New York, N.Y.) Vol. 26; no. 6; p. 816
• Main Authors: Du, Eugenie, Wenig, Bruce M, Su, Henry K, Rowe, Meghan E, Haser, Grace C, Asa, Sylvia L, Baloch, Zubair, Faquin, William C, Fellegara, Giovanni, Giordano, Thomas, Ghossein, Ronald, LiVolsi, Virginia A, Lloyd, Ricardo, Mete, Ozgur, Ozbek, Umut, Rosai, Juan, Suster, Saul, Thompson, Lester D, Turk, Andrew T, Urken, Mark L
• Format: Journal Article
• Language: English
• Published: United States 01.06.2016
• Subjects: Carcinoma, Papillary - pathology; Humans; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Observer Variation; Prognosis; Retrospective Studies; Thyroid Neoplasms - pathology

Extranodal extension (ENE) in lymph node metastases has been shown to worsen the prognosis of papillary thyroid cancer (PTC). Despite the clinical significance of ENE, there are no stringent criteria for its microscopic diagnosis, and its identification is subject to inter-observer variability. The...