In vitro zones of inhibition of coated vascular catheters predict efficacy in preventing catheter infection with Staphylococcus aureus in vivo

• Published in: European journal of clinical microbiology & infectious diseases Vol. 19; no. 8; pp. 612 - 617
• Main Authors: BASSETTI, S, HU, J, D'AGOSTINO, R. B, SHERERTZ, R. J
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.08.2000; Springer Nature B.V
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antimicrobial agents; Bacteremia - epidemiology; Bacteremia - microbiology; Biological and medical sciences; Catheters; Catheters, Indwelling - microbiology; Clinical trials; Confidence intervals; Disease Models, Animal; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical research; Medical sciences; Microbial Sensitivity Tests - methods; Miscellaneous. Technology; Nosocomial infections; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Predictive Value of Tests; Rabbits; Randomized Controlled Trials as Topic; Staphylococcal Infections - microbiology; Staphylococcal Infections - prevention & control; Staphylococcus aureus; Staphylococcus aureus - drug effects; United States > US; Instrumentation therapy; Catheter; Rabbit; Cardiovascular disease; Lagomorpha; In vitro; Vascularization; Vascular disease; Infection; Prevention; In vivo; Vertebrata; Mammalia; Animal; Risk factor; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Inhibition; Staphylococcus aureus

This report summarizes data from 35 rabbit model experiments investigating the relationship between in vitro anti-infective catheter coating zones of inhibition and in vivo efficacy. The rabbit model studies involving 15 anti-infective coatings demonstrate an inverse correlation between the sizes of...