Phase I metabolism of the highly potent synthetic cannabinoid MDMB-CHMICA and detection in human urine samples

• Published in: Drug testing and analysis Vol. 9; no. 5; p. 744
• Main Authors: Franz, Florian, Angerer, Verena, Moosmann, Bjoern, Auwärter, Volker
• Format: Journal Article
• Language: English
• Published: England 01.05.2017
• Subjects: Chromatography, Liquid - methods; Cyclic AMP - metabolism; Humans; Indoles - metabolism; Indoles - urine; Microsomes, Liver - metabolism; Psychotropic Drugs - metabolism; Psychotropic Drugs - urine; Spectrometry, Mass, Electrospray Ionization - methods; Street Drugs - metabolism; Street Drugs - urine; Substance Abuse Detection - methods; Tandem Mass Spectrometry - methods; LC-MS/MS; MMB-CHMINACA; new psychoactive substances; ADB-CHMICA; BB-22

Among the recently emerged synthetic cannabinoids, MDMB-CHMICA (methyl N-{[1-(cyclohexylmethyl)-1H-indol-3-yl]carbonyl}-3-methylvalinate) shows an extraordinarily high prevalence in intoxication cases, necessitating analytical methods capable of detecting drug uptake. In this study, the in vivo phas...