Novel artful applications of vaccines at the horizon

Some live vaccines, particularly Bacillus Calmette‐Guérin (BCG), oral polio vaccine (OPV), and measles vaccine, can reduce the incidence of all‐cause mortality by outreaching the mere control of specific infections and exerting off‐target effects. Asides from the prevention of viral infection, some...

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Published inPediatric Allergy and Immunology Vol. 33; no. S27; pp. 83 - 85
Main Authors Montin, Davide, Ottaviano, Giorgio, Sangerardi, Maria, Sgrulletti, Mayla, Chini, Loredana, Dellepiane, Rosa Maria, Martire, Baldassarre, Rizzo, Caterina, Moschese, Viviana, Marseglia, Gian Luigi
Format Journal Article Web Resource
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.01.2022
John Wiley & Sons, Inc
Subjects
Autoimmunity
BCG
BCG Vaccine
diabetes
Humans
Immune system
Immunity, Innate
Innate immunity
Measles
Measles Vaccine
mRNA vaccines
nonspecific effects
Rotavirus
Vaccines
Virus Diseases
autoimmunity
vaccines
BCG
mRNA vaccines
diabetes
measles
nonspecific effects
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Summary:Some live vaccines, particularly Bacillus Calmette‐Guérin (BCG), oral polio vaccine (OPV), and measles vaccine, can reduce the incidence of all‐cause mortality by outreaching the mere control of specific infections and exerting off‐target effects. Asides from the prevention of viral infection, some other vaccines, such as those against flu or rotavirus, could reduce the risk of developing autoimmunity. The nonspecific effects of vaccines are mediated by the innate immune system, mainly through the so‐called trained innate immunity. These observations paved the way for developing tolerogenic and trained immunity‐based vaccines with substantial implications for more effective use of vaccines and combat vaccine hesitancy.
Bibliography:ObjectType-Article-1
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ISSN:0905-6157
1399-3038
DOI:10.1111/pai.13638