Mycotoxin Fumonisin B1 Interferes Sphingolipid Metabolisms and Neural Tube Closure during Early Embryogenesis in Brown Tsaiya Ducks

• Published in: Toxins Vol. 13; no. 11; p. 743
• Main Authors: Lumsangkul, Chompunut, Tso, Ko-Hua, Fan, Yang-Kwang, Chiang, Hsin-I, Ju, Jyh-Cherng
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 20.10.2021; MDPI
• Subjects: Abnormalities; Animal feed; Animal species; Aquatic birds; Biosynthesis; Ceramide; Contaminants; Defects; duck embryos; early embryogenesis; Embryogenesis; Embryonic growth stage; Embryos; Feeds; Folic acid; Food contamination & poisoning; Fumonisin B1; Gene expression; Hamsters; Hedgehog protein; Lipid metabolism; Mammals; Metabolism; Morphology; Mycotoxins; Neural tube defects; Rabbits; Sphingomyelin; Toxicity; Waterfowl

Fumonisin B1 (FB1) is among the most common contaminants produced by Fusarium spp. fungus from corns and animal feeds. Although FB1 has been known to cause physical or functional defects of embryos in humans and several animal species such as Syrian hamsters, rabbits, and rodents, little is known ab...