The stretcher spontaneous neurodegenerative mutation models Charcot-Marie-Tooth disease type 4D [version 1; peer review: 3 approved]

• Published in: F1000 research Vol. 2; p. 46
• Main Authors: Chandler, David, Lopaticki, Sash, Huang, Dexing, Hunter, Michael, Angelicheva, Dora, Kilpatrick, Trevor, King, Rosalind HM, Kalaydjieva, Luba, Morahan, Grant
• Format: Journal Article
• Language: English
• Published: England F1000Research 2013; F1000 Research Ltd
• Subjects: Neurobiology of Disease & Regeneration; Neurogenetics; Peripheral Neuropathies

Mice affected by a spontaneous mutation which arose within our colony exhibited a neuromuscular phenotype involving tremor and characteristic stretching of the rear limbs. The mutant, named stretcher, was used to breed a backcross cohort for genetic mapping studies. The gene responsible for the muta...