Alzheimer's disease‐associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain - Readhead, Benjamin P.; Mastroeni, Diego F.; Wang, Qi; Sierra, Maria A.; Ávila, Camila; Jimoh, Tajudeen O.; Haure‐Mirande, Jean‐Vianney; Atanasoff, Kristina E.; Nolz, Jennifer; Suazo, Crystal; Barton, Nathaniel J.; Orszulak, Adrian R.; et al. (Alzheimer's & dementia, 2025)
Keywords: Aged; Aged, 80 and over; Alzheimer Disease - immunology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer Disease - virology; Alzheimer's disease; antibody epitope repertoire analysis; Antigens, CD - metabolism; Brain - immunology; Brain - metabolism; Brain - pathology; Brain - virology; CD83 Antigen; CD83(+) microglia; cerebrospinal fluid; Cytomegalovirus - immunology; Cytomegalovirus Infections - immunology; Female; human cytomegalovirus; Humans; Immunoglobulin G - cerebrospinal fluid; Immunoglobulin G - metabolism; immunoglobulin G4; Immunoglobulins - metabolism; immunohistochemistry; Male; Membrane Glycoproteins - metabolism; Microglia - immunology; Microglia - metabolism; prefrontal cortex; superior frontal gyrus; transverse colon; vagus nerve; Vagus Nerve - immunology; Vagus Nerve - metabolism; Vagus Nerve - virology; viral infection; transverse colon; vagus nerve; viral infection; CD83(+) microglia; prefrontal cortex; cerebrospinal fluid; antibody epitope repertoire analysis; immunohistochemistry; Alzheimer's disease; human cytomegalovirus; immunoglobulin G4; superior frontal gyrus