Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

• Published in: Journal of molecular biology Vol. 427; no. 1; pp. 3 - 30
• Main Authors: Payandeh, Jian, Minor, Daniel L.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 16.01.2015
• Subjects: channel gating; channel pharmacology; ion permeation; structural biology; voltage-gated sodium channel; VGIC; VSD; voltage-gated sodium channel; ion permeation; channel pharmacology; CTD; VSP; TRP; SF; CTC; PD; MD; HCS; structural biology; channel gating

Voltage-gated sodium channels (NaVs) provide the initial electrical signal that drives action potential generation in many excitable cells of the brain, heart, and nervous system. For more than 60years, functional studies of NaVs have occupied a central place in physiological and biophysical investi...