Prevalence and influence of cys407 Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour

• Published in: Neuropharmacology Vol. 115; pp. 128 - 138
• Main Authors: Wood, Christian M., Nicolas, Celine S., Choi, Sun-Lim, Roman, Erika, Nylander, Ingrid, Fernandez-Teruel, Alberto, Kiianmaa, Kalervo, Bienkowski, Przemyslaw, de Jong, Trynke R., Colombo, Giancarlo, Chastagnier, Denis, Wafford, Keith A., Collingridge, Graham L., Wildt, Sheryl J., Conway-Campbell, Becky L., Robinson, Emma S.J., Lodge, David
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.03.2017
• Subjects: Alcohol Drinking - genetics; Alcohol Drinking - psychology; Alcohol preference; Animals; Anxiety; Cystine - genetics; Emotionality; Emotions - physiology; Grm2 mutation; Han Wistar rats; Hippocampus - physiology; Metabotropic glutamate receptor; mGlu2; Mice, Knockout; Mutation - genetics; Organ Culture Techniques; Prevalence; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate - deficiency; Receptors, Metabotropic Glutamate - genetics; Risk-Taking; Selectively bred rats; Species Specificity; Wistar rats; Selectively bred rats; Wistar rats; Emotionality; Han Wistar rats; Alcohol preference; Grm2 mutation; Anxiety; Metabotropic glutamate receptor; mGlu2; RGD; mGlu2 receptor

Modulation of metabotropic glutamate 2 (mGlu2) receptor function has huge potential for treating psychiatric and neurological diseases. Development of drugs acting on mGlu2 receptors depends on the development and use of translatable animal models of disease. We report here a stop codon mutation at...