Macrophage inflammatory protein-1β as a novel therapeutic target for renal protection in diabetic kidney disease

• Published in: Biomedicine & pharmacotherapy Vol. 161; p. 114450
• Main Authors: Chang, Ting-Ting, Li, Szu-Yuan, Lin, Liang-Yu, Chen, Ching, Chen, Jaw-Wen
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.05.2023
• Subjects: Animals; Chemokine; Diabetes Mellitus - pathology; Diabetic kidney disease; Diabetic Nephropathies - pathology; Fibrosis; Inflammation; Inflammation - pathology; Kidney - pathology; Kidney - physiology; Macrophage inflammatory protein-1β; Mice; Mice, Knockout; Podocyte; Podocytes; IL; PAS; Inflammation; TNF; ACR; Chemokine; Podocyte; TGF; MIP-1β; Macrophage inflammatory protein-1β; Cre; BUN; DKD; HE; Diabetic kidney disease

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide and the prevalence of DKD has increased over recent decades. Inflammation is involved in the development and progression of DKD. In this study, we explored the potential role of macrophage inflammatory protein-1β...