Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function

• Published in: Inflammation research Vol. 73; no. 3; pp. 345 - 362
• Main Authors: Liang, Qing-hua, Li, Qiu-rong, Chen, Zhong, Lv, Li-juan, Lin, Yu, Jiang, Hong-lv, Wang, Ke-xin, Xiao, Ming-yue, Kang, Nai-xin, Tu, Peng-fei, Ji, Shi-liang, Deng, Ke-jun, Gao, Hong-wei, Zhang, Li, Li, Kun, Ge, Fei, Xu, Guo-qiang, Yang, Shi-lin, Liu, Yan-li, Xu, Qiong-ming
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2024; Springer Nature B.V
• Subjects: Affinity chromatography; Agonists; Allergology; Amino acids; Animal models; Biomedical and Life Sciences; Biomedicine; Biotin; Cell culture; Colitis; Dermatology; Dextran; Dextran sulfate; Dextrans; Dichloroacetic acid; Enzymatic activity; Immunology; In vivo methods and tests; Inflammation; Inflammatory bowel disease; Intestine; Lipopolysaccharides; Macrophages; Metabolism; Mice; Molecular docking; Molecular modelling; Mouse devices; Natural products; Neurology; NF-κB protein; Original Research Paper; Oxidative stress; Pharmacology/Toxicology; Protein structure; Proteomics; Pyruvate carboxylase; Pyruvic acid; Rheumatology; Saponins; Surface plasmon resonance; Tricarboxylic acid cycle; Anti-inflammatory target; Anemoside B4; Colitis; Pyruvate metabolism; Pyruvate carboxylase

Objectives Colitis is a global disease usually accompanied by intestinal epithelial damage and intestinal inflammation, and an increasing number of studies have found natural products to be highly effective in treating colitis. Anemoside B4 (AB4), an abundant saponin isolated from Pulsatilla chinens...