Cephalosporin-induced leukopenia following rechallenge with cefoxitin

• Published in: The Annals of pharmacotherapy Vol. 42; no. 9; p. 1327
• Main Authors: Whitman, Craig B, Joseph, Jomy M, Sjoholm, Lars O
• Format: Journal Article
• Language: English
• Published: United States 01.09.2008
• Subjects: Adult; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - therapeutic use; Bacterial Infections - drug therapy; Cefoxitin - adverse effects; Cefoxitin - therapeutic use; Humans; Leukocyte Count; Leukopenia - chemically induced; Male

To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin. A 22-year-old male was admitted after a motor vehicle crash. beta-Lactam therapy was initiated with vancomycin, cefepime, and metronidazole and, upon id...