Brain network topology and future development of freezing of gait in Parkinson’s disease: a longitudinal study

• Published in: Journal of neurology Vol. 269; no. 5; pp. 2503 - 2512
• Main Authors: Li, Nannan, Lei, Du, Peng, Jiaxin, Suo, Xueling, Li, Junying, Duan, Liren, Chen, Chaolan, Gong, Qiyong, Peng, Rong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2022; Springer Nature B.V
• Subjects: Brain - diagnostic imaging; Brain architecture; Cerebellum; Comparative analysis; Cortex (frontal); Frontal gyrus; Functional morphology; Gait; Gait Disorders, Neurologic - complications; Gait Disorders, Neurologic - etiology; Humans; Latency; Longitudinal Studies; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Movement disorders; Neurodegenerative diseases; Neurology; Neuroradiology; Neurosciences; Occipital lobe; Original Communication; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson's disease; Visual cortex; Freezing of gait; Graph theory; Magnetic resonance imaging; Brain networks; Parkinson’s disease
• ISSN: 0340-5354; 1432-1459; 1432-1459
• DOI: 10.1007/s00415-021-10817-x

Background Freezing of gait (FOG) is a common disabling gait disturbance in Parkinson’s disease (PD). The objectives of this study were to explore alterations in the topological organization of whole-brain functional networks in patients with PD who will develop FOG. Methods We recruited 20 patients...