Prediction of preeclampsia using maternal circulating mRNAs in early pregnancy

• Published in: Archives of gynecology and obstetrics Vol. 310; no. 1; pp. 327 - 335
• Main Authors: Chen, Jieyun, Xu, Xiuting, Xu, Xingneng, Yang, Si, Wang, Xuwei, Ye, Anqi, Yu, Bolan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2024; Springer Nature B.V
• Subjects: Adult; Area Under Curve; Biomarkers - blood; Case-Control Studies; Cell-Free Nucleic Acids - blood; Endocrinology; Female; Gynecology; Human Genetics; Humans; Logistic Models; Maternal-Fetal Medicine; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Placenta Growth Factor - blood; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Predictive Value of Tests; Preeclampsia; Pregnancy; Pregnancy Trimester, First - blood; Prospective Studies; RNA, Messenger - blood; Vascular Endothelial Growth Factor Receptor-1 - blood; Vascular Endothelial Growth Factor Receptor-1 - genetics; Circulating mRNA; Preeclampsia; Predictive model

Purpose Preeclampsia (PE) is one of the most common and serious complications of pregnancy, and novel methods for the early prediction of PE are needed for clinical application. Methods In this study, a circulating cell-free RNA (cfRNA) panel of target genes for PE prediction was designed and valida...