Lipopolysaccharide Exacerbates Ketamine-Induced Psychotic-Like Behavior, Oxidative Stress, and Neuroinflammation in Mice: Ameliorative Effect of Diosmin

• Published in: Journal of molecular neuroscience Vol. 73; no. 2-3; pp. 129 - 142
• Main Authors: Eneni, Aya-Ebi Okubo, Ben-Azu, Benneth, Ajayi, Abayomi Mayowa, Aderibibge, Adegbuyi Oladele
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2023; Springer Nature B.V
• Subjects: Animal models; Animals; Behavior; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cognition; Diosmin - pharmacology; Diosmin - therapeutic use; Dopamine; Glutamic acid receptors; Humans; Hypotheses; Inflammation; Interleukin 6; Ketamine; Ketamine - pharmacology; Lipopolysaccharides; Lipopolysaccharides - toxicity; Memory; Mental disorders; Mice; N-Methyl-D-aspartic acid receptors; Neurochemistry; Neuroinflammatory Diseases; Neurology; Neurosciences; Neurotransmission; Nitrites; Oxidative Stress; Pathogenesis; Proteomics; Risperidone; Schizophrenia; Social behavior; Social interactions; Stereotyped behavior; Superoxide Dismutase - metabolism; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-α; Schizophrenia; Lipopolysaccharide; Oxidative stress; Neuroinflammation; Ketamine; Diosmin

Schizophrenia, a neuropsychiatric disorder has been associated with aberrant neurotransmission affecting behaviors, social preference, and cognition. Limitations in understanding its pathogenesis via the dopamine hypothesis have engendered other hypotheses such as the glutamate hypothesis. That anta...