Nd-Mn Molecular Cluster with Searched Targets for Oral Cancer Imaging
In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between gen...
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| Published in | Molecular imaging and biology Vol. 25; no. 5; pp. 875 - 886 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cham
Springer International Publishing
01.10.2023
Springer Nature B.V |
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| Abstract | In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between genes. After clustering, correlation of clinical information, and gene functional enrichment analysis, MMP1 was predicted to be a biomarker/therapeutic target for OSCC cells. To obtain rare-earth probes with better luminescence in the NIR II region, we adjusted the doping ratio of the rare-earth element (Nd, Gd, Er, and Yb) fraction of the Nd-Mn molecular cluster to optimize its luminescence properties. The results of
in vitro
targeting experiments showed that Nd-Mn-MMP1Ab can target Cal-27 cells, demonstrating at the cellular level that the MMP1 gene is a biomarker for oral cancer, which also proves that the cancer targets predicted by the bioinformatics approach are correct. |
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| AbstractList | In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between genes. After clustering, correlation of clinical information, and gene functional enrichment analysis, MMP1 was predicted to be a biomarker/therapeutic target for OSCC cells. To obtain rare-earth probes with better luminescence in the NIR II region, we adjusted the doping ratio of the rare-earth element (Nd, Gd, Er, and Yb) fraction of the Nd-Mn molecular cluster to optimize its luminescence properties. The results of in vitro targeting experiments showed that Nd-Mn-MMP1Ab can target Cal-27 cells, demonstrating at the cellular level that the MMP1 gene is a biomarker for oral cancer, which also proves that the cancer targets predicted by the bioinformatics approach are correct. In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between genes. After clustering, correlation of clinical information, and gene functional enrichment analysis, MMP1 was predicted to be a biomarker/therapeutic target for OSCC cells. To obtain rare-earth probes with better luminescence in the NIR II region, we adjusted the doping ratio of the rare-earth element (Nd, Gd, Er, and Yb) fraction of the Nd-Mn molecular cluster to optimize its luminescence properties. The results of in vitro targeting experiments showed that Nd-Mn-MMP1Ab can target Cal-27 cells, demonstrating at the cellular level that the MMP1 gene is a biomarker for oral cancer, which also proves that the cancer targets predicted by the bioinformatics approach are correct.In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between genes. After clustering, correlation of clinical information, and gene functional enrichment analysis, MMP1 was predicted to be a biomarker/therapeutic target for OSCC cells. To obtain rare-earth probes with better luminescence in the NIR II region, we adjusted the doping ratio of the rare-earth element (Nd, Gd, Er, and Yb) fraction of the Nd-Mn molecular cluster to optimize its luminescence properties. The results of in vitro targeting experiments showed that Nd-Mn-MMP1Ab can target Cal-27 cells, demonstrating at the cellular level that the MMP1 gene is a biomarker for oral cancer, which also proves that the cancer targets predicted by the bioinformatics approach are correct. In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between genes. After clustering, correlation of clinical information, and gene functional enrichment analysis, MMP1 was predicted to be a biomarker/therapeutic target for OSCC cells. To obtain rare-earth probes with better luminescence in the NIR II region, we adjusted the doping ratio of the rare-earth element (Nd, Gd, Er, and Yb) fraction of the Nd-Mn molecular cluster to optimize its luminescence properties. The results of in vitro targeting experiments showed that Nd-Mn-MMP1Ab can target Cal-27 cells, demonstrating at the cellular level that the MMP1 gene is a biomarker for oral cancer, which also proves that the cancer targets predicted by the bioinformatics approach are correct. |
| Author | Tao, Xiaofeng Li, Wenjing Hui, Xin Yuan, Ying Wang, Yanxing Lv, Ruichan |
| Author_xml | – sequence: 1 givenname: Xin surname: Hui fullname: Hui, Xin organization: Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University – sequence: 2 givenname: Yanxing surname: Wang fullname: Wang, Yanxing organization: Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University – sequence: 3 givenname: Wenjing surname: Li fullname: Li, Wenjing organization: Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University – sequence: 4 givenname: Ying surname: Yuan fullname: Yuan, Ying organization: Department of Medical Interdisciplinary Research, Xi’an Ninth Hospital Affiliated to Medical College of Xi’an Jiaotong University – sequence: 5 givenname: Xiaofeng surname: Tao fullname: Tao, Xiaofeng email: cjr.taoxiaofeng@vip.163.com organization: Department of Medical Interdisciplinary Research, Xi’an Ninth Hospital Affiliated to Medical College of Xi’an Jiaotong University – sequence: 6 givenname: Ruichan orcidid: 0000-0002-6360-6478 surname: Lv fullname: Lv, Ruichan email: rclv@xidian.edu.cn organization: Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37256508$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.apsb.2016.11.001 10.3322/caac.21392 10.1007/s11864-017-0484-y 10.1093/bib/bbaa001 10.1097/CM9.0000000000001474 10.1007/s13258-021-01137-5 10.3389/fonc.2018.00374 10.1016/j.oraloncology.2018.03.004 10.1021/cr4001594 10.1007/s00192-022-05113-9 10.1016/j.matbio.2015.03.002 10.1016/j.exer.2017.10.007 10.1186/s13040-017-0155-3 10.1111/nph.17618 10.1016/S0140-6736(21)01550-6 10.1016/j.csbj.2014.11.005 10.1016/j.semcancer.2019.09.011 10.1016/j.jmoldx.2017.11.003 10.1093/carcin/bgt208 10.18637/jss.v046.i11 10.1007/s10067-021-05960-9 10.1093/bib/bbz170 10.1016/j.exer.2014.07.014 10.21037/atm-20-4634 10.1186/s12967-020-02683-4 10.1038/s41572-020-0156-2 10.1016/bs.mie.2016.09.016 |
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| Keywords | Near infrared II region Oral squamous cell carcinoma Weighted gene co-expression network analysis |
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| References | Cui, Merritt, Fu, Pan (CR8) 2017; 7 Gai, Li, Yang, Lin (CR12) 2014; 114 Cao, Chen, Yu, Li, Chen (CR5) 2021; 134 Karim, Beyan, Zappa (CR21) 2021; 22 Rohani, Parks (CR30) 2015; 44–46 Chen, Liao, Yao, Wang, Fu (CR29) 2022; 41 Joseph, Harishankar, Pillai, Devi (CR7) 2018; 80 Zhao, Zhang, Wang (CR15) 2021; 19 Roy, Coldren, Karunamurthy (CR13) 2018; 20 Bao, Zhang, Bao (CR16) 2021; 43 Chicco (CR28) 2017; 10 Vranka, Kelley, Acott, Keller (CR26) 2015; 133 Mody, Rocco, Yom, Haddad, Saba (CR3) 2021; 398 Johnson, Burtness, Leemans, Lui, Bauman, Grandis (CR2) 2020; 6 Chai, Lim, Cheong (CR4) 2020; 61 Smith, Andrews, Brooks (CR10) 2017; 67 Niemira, Collin, Szalkowska (CR23) 2020; 12 Rivera (CR9) 2015; 8 Clarke, Madden, Doolan (CR18) 2013; 34 Wan, Tang, Han, Wang (CR17) 2018; 166 CR24 Chen, Wang, Sun (CR11) 2021; 22 Langfelder, Horvath (CR19) 2012; 46 Huang, O'Sullivan (CR1) 2017; 18 Hanna, King, Thibodeau (CR6) 2020; 371 Li, Lai, Liu, Li, Guo, Xu (CR20) 2022; 33 Tang, Kong, Cui (CR25) 2018; 8 Wang, Shu, Zhang (CR14) 2022; 233 Kourou, Exarchos, Exarchos, Karamouzis, Fotiadis (CR22) 2015; 13 Chen, Yang, Liu (CR27) 2021; 9 C Cui (1828_CR8) 2017; 7 MD Mody (1828_CR3) 2021; 398 P Langfelder (1828_CR19) 2012; 46 JA Vranka (1828_CR26) 2015; 133 D Chicco (1828_CR28) 2017; 10 C Rivera (1828_CR9) 2015; 8 K Li (1828_CR20) 2022; 33 K Kourou (1828_CR22) 2015; 13 J Tang (1828_CR25) 2018; 8 X Zhao (1828_CR15) 2021; 19 MG Rohani (1828_CR30) 2015; 44–46 W Cao (1828_CR5) 2021; 134 S Gai (1828_CR12) 2014; 114 Q Wan (1828_CR17) 2018; 166 MR Karim (1828_CR21) 2021; 22 M Niemira (1828_CR23) 2020; 12 S Chen (1828_CR27) 2021; 9 L Chen (1828_CR11) 2021; 22 C Clarke (1828_CR18) 2013; 34 JP Joseph (1828_CR7) 2018; 80 AWY Chai (1828_CR4) 2020; 61 R Wang (1828_CR14) 2022; 233 Q Bao (1828_CR16) 2021; 43 TP Hanna (1828_CR6) 2020; 371 S Roy (1828_CR13) 2018; 20 RA Smith (1828_CR10) 2017; 67 Y Chen (1828_CR29) 2022; 41 SH Huang (1828_CR1) 2017; 18 DE Johnson (1828_CR2) 2020; 6 1828_CR24 |
| References_xml | – volume: 6 start-page: 22 year: 2020 ident: CR2 article-title: Head and neck squamous cell carcinoma publication-title: Nat Rev Dis Prim – volume: 7 start-page: 3 year: 2017 end-page: 17 ident: CR8 article-title: Targeting calcium signaling in cancer therapy publication-title: Acta Pharmaceutica Sinica B doi: 10.1016/j.apsb.2016.11.001 – volume: 67 start-page: 100 year: 2017 end-page: 121 ident: CR10 article-title: Cancer screening in the United States, 2017: a review of current American Cancer Society guidelines and current issues in cancer screening publication-title: Ca-a Cancer J Clin doi: 10.3322/caac.21392 – volume: 18 start-page: 13 year: 2017 ident: CR1 article-title: Overview of the 8th edition TNM classification for head and neck cancer publication-title: Curr Treat Options Oncol doi: 10.1007/s11864-017-0484-y – volume: 8 start-page: 11884 year: 2015 end-page: 11894 ident: CR9 article-title: Essentials of oral cancer publication-title: Int J Clin Exp Pathol – volume: 22 start-page: 1706 year: 2021 end-page: 1728 ident: CR11 article-title: The bioinformatics toolbox for circRNA discovery and analysis publication-title: Brief Bioinform doi: 10.1093/bib/bbaa001 – volume: 134 start-page: 783 year: 2021 end-page: 791 ident: CR5 article-title: Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020 publication-title: Chin Med J doi: 10.1097/CM9.0000000000001474 – volume: 43 start-page: 1231 year: 2021 end-page: 1246 ident: CR16 article-title: Using weighted gene co-expression network analysis (WGCNA) to identify the hub genes related to hypoxic adaptation in yak (Bos grunniens) publication-title: Genes Genomics doi: 10.1007/s13258-021-01137-5 – volume: 8 start-page: 13 year: 2018 ident: CR25 article-title: Prognostic genes of breast cancer identified by gene co-expression network analysis publication-title: Front Oncol doi: 10.3389/fonc.2018.00374 – volume: 80 start-page: 23 year: 2018 end-page: 32 ident: CR7 article-title: Hypoxia induced EMT: a review on the mechanism of tumor progression and metastasis in OSCC publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2018.03.004 – volume: 114 start-page: 2343 year: 2014 end-page: 2389 ident: CR12 article-title: Recent progress in rare earth micro/nanocrystals: soft chemical synthesis, luminescent properties, and biomedical applications publication-title: Chem Rev doi: 10.1021/cr4001594 – volume: 33 start-page: 2241 year: 2022 end-page: 2249 ident: CR20 article-title: WGCNA and molecular docking reveal key hub genes and potential natural inhibitor in interstitial cystitis/bladder pain syndrome publication-title: Int Urogynecol J doi: 10.1007/s00192-022-05113-9 – volume: 44–46 start-page: 113 year: 2015 end-page: 121 ident: CR30 article-title: Matrix remodeling by MMPs during wound repair publication-title: Matrix Biol doi: 10.1016/j.matbio.2015.03.002 – volume: 166 start-page: 13 year: 2018 end-page: 20 ident: CR17 article-title: Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma publication-title: Exp Eye Res doi: 10.1016/j.exer.2017.10.007 – volume: 371 start-page: 27 year: 2020 ident: CR6 article-title: Mortality due to cancer treatment delay: systematic review and meta-analysis publication-title: Bmj-Br Med J – volume: 10 start-page: 17 year: 2017 ident: CR28 article-title: Ten quick tips for machine learning in computational biology publication-title: Biodata Min doi: 10.1186/s13040-017-0155-3 – volume: 233 start-page: 373 year: 2022 end-page: 389 ident: CR14 article-title: Integrative analyses of metabolome and genome-wide transcriptome reveal the regulatory network governing flavor formation in kiwifruit (Actinidia chinensis) publication-title: New Phytol doi: 10.1111/nph.17618 – volume: 398 start-page: 2289 year: 2021 end-page: 2299 ident: CR3 article-title: Head and neck cancer publication-title: Lancet doi: 10.1016/S0140-6736(21)01550-6 – volume: 13 start-page: 8 year: 2015 end-page: 17 ident: CR22 article-title: Machine learning applications in cancer prognosis and prediction publication-title: Comput Struct Biotechnol J doi: 10.1016/j.csbj.2014.11.005 – volume: 12 start-page: 24 year: 2020 ident: CR23 article-title: Molecular signature of subtypes of non-small-cell lung cancer by large-scale transcriptional profiling: identification of key modules and genes by weighted gene co-expression network analysis (WGCNA) publication-title: Cancers – volume: 61 start-page: 71 year: 2020 end-page: 83 ident: CR4 article-title: Translational genomics and recent advances in oral squamous cell carcinoma publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2019.09.011 – volume: 20 start-page: 4 year: 2018 end-page: 27 ident: CR13 article-title: Standards and guidelines for validating next-generation sequencing bioinformatics pipelines: a joint recommendation of the Association for Molecular Pathology and the College of American Pathologists publication-title: J Mol Diagn doi: 10.1016/j.jmoldx.2017.11.003 – volume: 34 start-page: 2300 year: 2013 end-page: 2308 ident: CR18 article-title: Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis publication-title: Carcinogenesis doi: 10.1093/carcin/bgt208 – volume: 46 start-page: 1 year: 2012 end-page: 17 ident: CR19 article-title: Fast R functions for robust correlations and hierarchical clustering publication-title: J Stat Softw doi: 10.18637/jss.v046.i11 – volume: 19 start-page: 1 year: 2021 ident: CR15 article-title: Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis publication-title: J Transl Med – volume: 9 start-page: 13 year: 2021 ident: CR27 article-title: Identification of crucial genes mediating abdominal aortic aneurysm pathogenesis based on gene expression profiling of perivascular adipose tissue by WGCNA publication-title: Ann Transl Med – volume: 41 start-page: 1057 year: 2022 end-page: 1068 ident: CR29 article-title: Machine learning to identify immune-related biomarkers of rheumatoid arthritis based on WGCNA network publication-title: Clin Rheumatol doi: 10.1007/s10067-021-05960-9 – ident: CR24 – volume: 22 start-page: 393 year: 2021 end-page: 415 ident: CR21 article-title: Deep learning-based clustering approaches for bioinformatics publication-title: Brief Bioinform doi: 10.1093/bib/bbz170 – volume: 133 start-page: 112 year: 2015 end-page: 125 ident: CR26 article-title: Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma publication-title: Exp Eye Res doi: 10.1016/j.exer.2014.07.014 – volume: 7 start-page: 3 year: 2017 ident: 1828_CR8 publication-title: Acta Pharmaceutica Sinica B doi: 10.1016/j.apsb.2016.11.001 – volume: 22 start-page: 393 year: 2021 ident: 1828_CR21 publication-title: Brief Bioinform doi: 10.1093/bib/bbz170 – volume: 33 start-page: 2241 year: 2022 ident: 1828_CR20 publication-title: Int Urogynecol J doi: 10.1007/s00192-022-05113-9 – volume: 41 start-page: 1057 year: 2022 ident: 1828_CR29 publication-title: Clin Rheumatol doi: 10.1007/s10067-021-05960-9 – volume: 34 start-page: 2300 year: 2013 ident: 1828_CR18 publication-title: Carcinogenesis doi: 10.1093/carcin/bgt208 – volume: 9 start-page: 13 year: 2021 ident: 1828_CR27 publication-title: Ann Transl Med doi: 10.21037/atm-20-4634 – volume: 20 start-page: 4 year: 2018 ident: 1828_CR13 publication-title: J Mol Diagn doi: 10.1016/j.jmoldx.2017.11.003 – volume: 398 start-page: 2289 year: 2021 ident: 1828_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(21)01550-6 – volume: 233 start-page: 373 year: 2022 ident: 1828_CR14 publication-title: New Phytol doi: 10.1111/nph.17618 – volume: 13 start-page: 8 year: 2015 ident: 1828_CR22 publication-title: Comput Struct Biotechnol J doi: 10.1016/j.csbj.2014.11.005 – volume: 12 start-page: 24 year: 2020 ident: 1828_CR23 publication-title: Cancers – volume: 22 start-page: 1706 year: 2021 ident: 1828_CR11 publication-title: Brief Bioinform doi: 10.1093/bib/bbaa001 – volume: 134 start-page: 783 year: 2021 ident: 1828_CR5 publication-title: Chin Med J doi: 10.1097/CM9.0000000000001474 – volume: 371 start-page: 27 year: 2020 ident: 1828_CR6 publication-title: Bmj-Br Med J – volume: 166 start-page: 13 year: 2018 ident: 1828_CR17 publication-title: Exp Eye Res doi: 10.1016/j.exer.2017.10.007 – volume: 67 start-page: 100 year: 2017 ident: 1828_CR10 publication-title: Ca-a Cancer J Clin doi: 10.3322/caac.21392 – volume: 19 start-page: 1 year: 2021 ident: 1828_CR15 publication-title: J Transl Med doi: 10.1186/s12967-020-02683-4 – volume: 43 start-page: 1231 year: 2021 ident: 1828_CR16 publication-title: Genes Genomics doi: 10.1007/s13258-021-01137-5 – volume: 18 start-page: 13 year: 2017 ident: 1828_CR1 publication-title: Curr Treat Options Oncol doi: 10.1007/s11864-017-0484-y – volume: 61 start-page: 71 year: 2020 ident: 1828_CR4 publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2019.09.011 – volume: 10 start-page: 17 year: 2017 ident: 1828_CR28 publication-title: Biodata Min doi: 10.1186/s13040-017-0155-3 – volume: 6 start-page: 22 year: 2020 ident: 1828_CR2 publication-title: Nat Rev Dis Prim doi: 10.1038/s41572-020-0156-2 – ident: 1828_CR24 doi: 10.1016/bs.mie.2016.09.016 – volume: 46 start-page: 1 year: 2012 ident: 1828_CR19 publication-title: J Stat Softw doi: 10.18637/jss.v046.i11 – volume: 80 start-page: 23 year: 2018 ident: 1828_CR7 publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2018.03.004 – volume: 44–46 start-page: 113 year: 2015 ident: 1828_CR30 publication-title: Matrix Biol doi: 10.1016/j.matbio.2015.03.002 – volume: 8 start-page: 11884 year: 2015 ident: 1828_CR9 publication-title: Int J Clin Exp Pathol – volume: 8 start-page: 13 year: 2018 ident: 1828_CR25 publication-title: Front Oncol doi: 10.3389/fonc.2018.00374 – volume: 114 start-page: 2343 year: 2014 ident: 1828_CR12 publication-title: Chem Rev doi: 10.1021/cr4001594 – volume: 133 start-page: 112 year: 2015 ident: 1828_CR26 publication-title: Exp Eye Res doi: 10.1016/j.exer.2014.07.014 |
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| Snippet | In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells.... |
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| SubjectTerms | Bioinformatics Biomarkers Cancer Clustering Erbium Gadolinium Gene expression Gene set enrichment analysis Imaging Interstitial collagenase Luminescence Medicine Medicine & Public Health Neodymium Network analysis Optical properties Oral cancer Oral carcinoma Oral squamous cell carcinoma Radiology Rare earth elements Research Article Squamous cell carcinoma Therapeutic targets Ytterbium |
| Title | Nd-Mn Molecular Cluster with Searched Targets for Oral Cancer Imaging |
| URI | https://link.springer.com/article/10.1007/s11307-023-01828-3 https://www.ncbi.nlm.nih.gov/pubmed/37256508 https://www.proquest.com/docview/2881351357 https://www.proquest.com/docview/2821341708 |
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