Hierarchical cluster analysis of cytokine profiles reveals a cutaneous vasculitis-associated subgroup in dermatomyositis

• Published in: Clinical rheumatology Vol. 40; no. 3; pp. 999 - 1008
• Main Authors: Bai, Jingjing, Wu, Chanyuan, Zhong, Danli, Xu, Dong, Wang, Qian, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2021; Springer Nature B.V
• Subjects: Autoimmune diseases; Cluster Analysis; Correlation analysis; Cytokines; Dermatomyositis; Dermatomyositis - complications; Humans; Interleukin 1 receptor antagonist; Interleukin 1 receptors; Interleukin 22; Interleukin 6; Interleukin 7; Interleukin 8; IP-10 protein; Medicine; Medicine & Public Health; Monocyte chemoattractant protein 1; Myositis; Original Article; Phenotypes; RANTES; Regression analysis; Rheumatology; Serum levels; Tumor Necrosis Factor-alpha; Tumor necrosis factor-α; Vasculitis; α-Interferon; γ-Interferon; Cluster analysis; Cutaneous vasculitis; Cytokine; Dermatomyositis

Objectives Dermatomyositis (DM) is a chronic inflammatory autoimmune disease with notable heterogeneity. The intent of this study was to explore the difference in cytokine profiles of different subsets in DM based on the disease activity and myositis-specific antibodies, and to identify the clinical...