Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses

• Published in: Inflammation research Vol. 73; no. 5; pp. 771 - 792
• Main Authors: Valverde, Araceli, Naqvi, Raza Ali, Naqvi, Afsar R.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2024; Springer Nature B.V
• Subjects: Allergology; Antigen processing; Antigens; Arrays; Biomarkers; Biomedical and Life Sciences; Biomedicine; Biopsy; Cell Differentiation; Cells, Cultured; Cytokines; Cytokines - metabolism; Cytoskeleton; Dermatology; Differentiation; Enrichment; Epigenetics; Flow cytometry; Functionals; Gingiva - immunology; Gum disease; Humans; Immune response; Immune system; Immunity, Innate; Immunology; Inflammation; Innate immunity; Leukocyte migration; Macrophages; Macrophages - immunology; Monocytes; Neurology; Non-coding RNA; Original Research Paper; Periodontitis; Periodontitis - genetics; Periodontitis - immunology; Phagocytosis; Pharmacology/Toxicology; Polarization; Rheumatology; RNA, Long Noncoding - genetics; Signal transduction; Transcriptomes; Periodontal inflammation; Macrophage polarization; Long noncoding RNA; Immunity; Phagocytosis

Introduction Macrophages (Mφs) are functionally dynamic immune cells that bridge innate and adaptive immune responses; however, the underlying epigenetic mechanisms that control Mφ plasticity and innate immune functions are not well elucidated. Objective To identify novel functions of macrophage-enr...