The Effect of Chronic Morphine or Methadone Exposure and Withdrawal on Clock Gene Expression in the Rat Suprachiasmatic Nucleus and AA-NAT Activity in the Pineal Gland

• Published in: Physiological research Vol. 65; no. 3; pp. 517 - 525
• Main Authors: PAČESOVÁ, D., NOVOTNÝ, J., BENDOVÁ, Z.
• Format: Journal Article
• Language: English
• Published: Czech Republic Institute of Physiology 18.07.2016
• Subjects: Addictions; Addictive behaviors; Animals; Arginine Vasopressin - metabolism; Behavior; Circadian rhythm; Circadian Rhythm - drug effects; Endocrine system; Experiments; Gene expression; In Situ Hybridization; Kinases; Male; Methadone - adverse effects; Morphine - adverse effects; Narcotics; Narcotics - adverse effects; Period Circadian Proteins - metabolism; Rats, Wistar; Rodents; Sleep; Substance Withdrawal Syndrome - metabolism; Suprachiasmatic Nucleus - drug effects; Suprachiasmatic Nucleus - metabolism

The circadian rhythms of many behavioral and physiological functions are regulated by the major circadian pacemaker in the suprachiasmatic nucleus. Long-term opiate addiction and drug withdrawal may affect circadian rhythmicity of various hormones or the sleep/activity pattern of many experimental s...