Identification of potential inhibitors of cholinergic and β-secretase enzymes from phytochemicals derived from Gongronema latifolium Benth leaf: an integrated computational analysis - Gyebi, Gideon Ampoma; Ogunyemi, Oludare M.; Ibrahim, Ibrahim M.; Ogunro, Olalekan B.; Afolabi, Saheed O.; Ojo, Rotimi J.; Anyanwu, Gabriel O.; El-Saber Batiha, Gaber; Adebayo, Joseph O. (Molecular diversity, 2024)
Keywords: Acetylcholinesterase - chemistry; Acetylcholinesterase - metabolism; Amyloid Precursor Protein Secretases - antagonists & inhibitors; Amyloid Precursor Protein Secretases - chemistry; Amyloid Precursor Protein Secretases - metabolism; Aspartic Acid Endopeptidases - antagonists & inhibitors; Aspartic Acid Endopeptidases - chemistry; Aspartic Acid Endopeptidases - metabolism; Biochemistry; Biomedical and Life Sciences; Butyrylcholinesterase - chemistry; Butyrylcholinesterase - metabolism; Cholinesterase Inhibitors - chemistry; Cholinesterase Inhibitors - pharmacology; Cluster analysis; Enzymes; Humans; Life Sciences; Molecular Docking Simulation; Molecular Dynamics Simulation; Organic Chemistry; Original Article; Pharmacy; Phytochemicals; Phytochemicals - chemistry; Phytochemicals - pharmacology; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Polymer Sciences; Molecular dynamic simulation; Silymarin; Acetylcholinesterase; Butyrylcholinesterase; Neurodegenerative disorders; Molecular docking