Translational Regulation by Upstream Open Reading Frames and Human Diseases

• Published in: Advances in experimental medicine and biology Vol. 1157; p. 99
• Main Authors: Silva, Joana, Fernandes, Rafael, Romão, Luísa
• Format: Journal Article
• Language: English
• Published: United States 01.01.2019
• Subjects: uORF-encoded peptide; Translatome; uORF; Translational regulation; Non-AUG upstream open reading frame (uORF); Stress; Genetic disease

Short upstream open reading frames (uORFs) are cis-acting elements located within the 5'-leader sequence of transcripts and are defined by an initiation codon in-frame with a termination codon located upstream or downstream of its main ORF (mORF) initiation codon. Recent genome-wide ribosome pr...