Unknown primary squamous cell carcinoma of the head and neck: retrospective analysis of 80 cases
The management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current multicenter retrospective study investigated the treatment outcomes of patients with HNCUP. The study included patients who were treated curatively at 12 institu...
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Published in | Acta oto-laryngologica Vol. 138; no. 6; pp. 590 - 596 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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England
03.06.2018
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Abstract | The management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current multicenter retrospective study investigated the treatment outcomes of patients with HNCUP.
The study included patients who were treated curatively at 12 institutions in Japan from January 2006 to December 2015.
Eighty patients with HNCUP were included. The median follow-up period was 34 months. The three-year overall survival (OS), disease-specific survival (DSS), regional relapse-free survival (RRFS), local progression-free survival (LPFS), and distant metastasis-free survival (DMFS) rates were 72.5%, 80.3%, 74.0%, 89.7%, and 86.9%, respectively. Nodal status was a significant factor for OS, DSS, RRFS, and DMFS; and extracapsular extension (ECE) was significant for OS and DSS. There was a distinct difference between the survival rates of patients with N1-2a and N2b-3 disease. RT was a significant positive factor for LPFS (3-year LPFS, RT 93.0% vs. no RT 83.0%, p = .043).
For N2a as well as N1 disease without ECE, a single treatment modality, including ND or RT alone is acceptable. When ND alone is performed, thorough monitoring should be continued during follow-up to identify the emergence of the primary lesion. |
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AbstractList | The management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current multicenter retrospective study investigated the treatment outcomes of patients with HNCUP.
The study included patients who were treated curatively at 12 institutions in Japan from January 2006 to December 2015.
Eighty patients with HNCUP were included. The median follow-up period was 34 months. The three-year overall survival (OS), disease-specific survival (DSS), regional relapse-free survival (RRFS), local progression-free survival (LPFS), and distant metastasis-free survival (DMFS) rates were 72.5%, 80.3%, 74.0%, 89.7%, and 86.9%, respectively. Nodal status was a significant factor for OS, DSS, RRFS, and DMFS; and extracapsular extension (ECE) was significant for OS and DSS. There was a distinct difference between the survival rates of patients with N1-2a and N2b-3 disease. RT was a significant positive factor for LPFS (3-year LPFS, RT 93.0% vs. no RT 83.0%, p = .043).
For N2a as well as N1 disease without ECE, a single treatment modality, including ND or RT alone is acceptable. When ND alone is performed, thorough monitoring should be continued during follow-up to identify the emergence of the primary lesion. OBJECTIVESThe management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current multicenter retrospective study investigated the treatment outcomes of patients with HNCUP.METHODSThe study included patients who were treated curatively at 12 institutions in Japan from January 2006 to December 2015.RESULTSEighty patients with HNCUP were included. The median follow-up period was 34 months. The three-year overall survival (OS), disease-specific survival (DSS), regional relapse-free survival (RRFS), local progression-free survival (LPFS), and distant metastasis-free survival (DMFS) rates were 72.5%, 80.3%, 74.0%, 89.7%, and 86.9%, respectively. Nodal status was a significant factor for OS, DSS, RRFS, and DMFS; and extracapsular extension (ECE) was significant for OS and DSS. There was a distinct difference between the survival rates of patients with N1-2a and N2b-3 disease. RT was a significant positive factor for LPFS (3-year LPFS, RT 93.0% vs. no RT 83.0%, p = .043).CONCLUSIONSFor N2a as well as N1 disease without ECE, a single treatment modality, including ND or RT alone is acceptable. When ND alone is performed, thorough monitoring should be continued during follow-up to identify the emergence of the primary lesion. |
Author | Shinohara, Shogo Asato, Ryo Kitamura, Morimasa Ushiro, Koji Honda, Keigo Tateya, Ichiro Tanaka, Shinzo Ichimaru, Kazuyuki Mizuta, Masanobu Kojima, Tsuyoshi Yamada, Koichiro Tamaki, Hisanobu Maetani, Toshiki Kumabe, Yohei Kitani, Yoshiharu Omori, Koichi Takebayashi, Shinji |
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Snippet | The management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current multicenter... OBJECTIVESThe management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current... |
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SubjectTerms | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - therapy Female Head and Neck Neoplasms - mortality Head and Neck Neoplasms - secondary Head and Neck Neoplasms - therapy Humans Japan - epidemiology Male Middle Aged Neoplasms, Unknown Primary - mortality Neoplasms, Unknown Primary - therapy Retrospective Studies |
Title | Unknown primary squamous cell carcinoma of the head and neck: retrospective analysis of 80 cases |
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