Update on the management of fungal keratitis

Purpose The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years. Methods We performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatme...

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Published inInternational ophthalmology Vol. 41; no. 9; pp. 3249 - 3256
Main Authors Sha, Xiao-Yuan, Shi, Qi, Liu, Lian, Zhong, Jing-Xiang
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.09.2021
Springer Nature B.V
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Abstract Purpose The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years. Methods We performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis. Results Excessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology. Conclusion The diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems.
AbstractList The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years.PURPOSEThe aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years.We performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis.METHODSWe performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis.Excessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology.RESULTSExcessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology.The diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems.CONCLUSIONThe diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems.
The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years. We performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis. Excessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology. The diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems.
PurposeThe aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years.MethodsWe performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis.ResultsExcessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology.ConclusionThe diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems.
Purpose The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years. Methods We performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis. Results Excessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology. Conclusion The diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems.
Author Zhong, Jing-Xiang
Shi, Qi
Sha, Xiao-Yuan
Liu, Lian
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Keywords Drug delivery systems
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Snippet Purpose The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years. Methods We performed...
The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years. We performed literature review of...
PurposeThe aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years.MethodsWe performed literature...
The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years.PURPOSEThe aim of this article is to...
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SubjectTerms Autophagy
Chemical compounds
Cornea
Cytokines
Diagnosis
Drug delivery
Drug delivery systems
Epidemiology
Fungi
Infections
Inflammation
Keratitis
Literature reviews
Medicine
Medicine & Public Health
Neutrophils
Ophthalmology
Pathogenesis
Pathogens
Pharmacology
Reagents
Review
Therapeutic targets
Ulcers
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Title Update on the management of fungal keratitis
URI https://link.springer.com/article/10.1007/s10792-021-01873-3
https://www.ncbi.nlm.nih.gov/pubmed/33929644
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