High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in sonic hedgehog-medulloblastoma

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 26; no. 9; pp. 1685 - 1699
• Main Authors: Zhou, Leilei, van Bree, Niek, Boutin, Lola, Ryu, Jinhye, Moussaud, Simon, Liu, Mingzhi, Otrocka, Magdalena, Olsson, Magnus, Falk, Anna, Wilhelm, Margareta
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 05.09.2024
• Subjects: Medicin och hälsovetenskap; Pediatric Neuro-Oncology; precision cancer medicine; medulloblastoma; PF4708671; high-throughput drug screen; S6K1

Abstract Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current treatments have increased overall survival but can lead to devastating side effects and late complications in survivors, emphasizing the need for new, improved targeted therapies that speci...