Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis

• Published in: Journal of molecular neuroscience Vol. 72; no. 1; pp. 97 - 112
• Main Authors: Wang, Hui-Qi, Song, Kai-Yi, Feng, Jin-Zhou, Huang, Si-Yuan, Guo, Xiu-Ming, Zhang, Lei, Zhang, Gang, Huo, Ying-Chao, Zhang, Rong-Rong, Ma, Yue, Hu, Qing-Zhe, Qin, Xin-Yue
• Format: Journal Article
• Language: English
• Published: New York Springer US 2022; Springer Nature B.V
• Subjects: Autophagy; Biomedical and Life Sciences; Biomedicine; Caffeine; Cell Biology; Central nervous system; Demyelination; Encephalomyelitis; Experimental allergic encephalomyelitis; Immunization; Infiltration; Inflammasomes; Inflammation; Inflammatory response; Methylamine; Microglia; Neurochemistry; Neurology; Neurosciences; Proteomics; Pyrin protein; Rapamycin; siRNA; TOR protein; EAE; NLRP3 inflammasome; Autophagy; Caffeine; Microglia

The activation of microglia is an important cause of central nervous system (CNS) inflammatory cell infiltration and inflammatory demyelination in experimental autoimmune encephalomyelitis (EAE). Furthermore, the proinflammatory response induced by the NLR family pyrin domain containing 3 (NLRP3) in...