BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial–Mesenchymal Transition

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 6; pp. 1279 - 1292
• Main Authors: Sato, Masaki, Matsumoto, Mitsuyo, Saiki, Yuriko, Alam, Mahabub, Nishizawa, Hironari, Rokugo, Masahiro, Brydun, Andrey, Yamada, Shinji, Kaneko, Mika K., Funayama, Ryo, Ito, Mamoru, Kato, Yukinari, Nakayama, Keiko, Unno, Michiaki, Igarashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: United States 15.03.2020

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the poorest prognoses due to its highly malignant features. BTB and CNC homology 1 (BACH1) has been implicated in RAS-driven tumor formation. We focused on the role of BACH1 in PDAC, more than 90% of which have mutation. Knockdown of...