PFKFB3 facilitates cell proliferation and migration in anaplastic thyroid carcinoma via the WNT/β‐catenin signaling pathway

• Published in: Endocrine Vol. 85; no. 2; pp. 737 - 750
• Main Authors: Deng, Jinmei, Cheng, Yanglei, Li, Hai, He, Xiaoying, Yu, Shuang, Ma, Jiajing, Li, Xuhui, Chen, Jie, Xiao, Haipeng, Guan, Hongyu, Li, Yanbing
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2024; Springer Nature B.V
• Subjects: AKT protein; Animals; Cell growth; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Cyclin D1; Diabetes; Down-regulation; Endocrinology; Gelatinase B; Gene expression; Glycolysis; Humanities and Social Sciences; Humans; Immunohistochemistry; Internal Medicine; Kinases; Lactic acid; Medicine; Medicine & Public Health; Metalloproteinase; Metastases; Mice; Mice, Nude; Molecular modelling; multidisciplinary; Nuclear transport; Original Article; Phosphofructokinase-2 - genetics; Phosphofructokinase-2 - metabolism; Science; Signal transduction; Thyroid cancer; Thyroid carcinoma; Thyroid Carcinoma, Anaplastic - genetics; Thyroid Carcinoma, Anaplastic - metabolism; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Tumors; Western blotting; Wnt protein; Wnt Signaling Pathway; β-Catenin; PFKFB3; Proliferation; WNT/β‐catenin; Migration; Anaplastic thyroid carcinoma (ATC)

Purpose Despite the involvement of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase3 (PFKFB3) in the proliferation and metastasis of diverse tumor types, its biological functions and related molecular mechanisms in anaplastic thyroid carcinoma (ATC) remain largely unclear. Methods Datasets from t...