The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer

• Published in: Molecular cancer research Vol. 12; no. 5; pp. 670 - 680
• Main Authors: Rawnaq, Tamina, Dietrich, Luisa, Wolters-Eisfeld, Gerrit, Uzunoglu, Faik G, Vashist, Yogesh K, Bachmann, Kai, Simon, Ronald, Izbicki, Jakob R, Bockhorn, Maximilian, Güngör, Cenap
• Format: Journal Article
• Language: English
• Published: United States 01.05.2014
• Subjects: Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Cell Line, Tumor; Cell Movement - physiology; Cell Proliferation - physiology; Cytoplasm - metabolism; Female; Gene Knockdown Techniques; Humans; Immunohistochemistry; Male; Middle Aged; Nerve Growth Factors - biosynthesis; Nerve Growth Factors - genetics; Nerve Growth Factors - metabolism; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; RNA, Small Interfering - administration & dosage; RNA, Small Interfering - genetics; Signal Transduction; Transfection

Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis among solid tumors and despite increased knowledge of the molecular mechanisms contributing to progression and metastasis, minimal progress has been done in establishing new targeted therapies for this deadly disease. The expression...