miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons

• Published in: Journal of molecular neuroscience Vol. 71; no. 12; pp. 2593 - 2607
• Main Authors: Shvarts-Serebro, Inna, Sheinin, Anton, Gottfried, Irit, Adler, Lior, Schottlender, Nofar, Ashery, Uri, Barak, Boaz
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2021; Springer Nature B.V
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cells, Cultured; Cognitive ability; Degeneration; Enrichment; Excitability; Exposure; Gene expression; Hippocampus; Hippocampus - cytology; Hippocampus - metabolism; Mice; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Neural networks; Neurochemistry; Neurodegenerative diseases; Neurology; Neurons - metabolism; Neurosciences; Plasticity; Post-transcription; Proteins; Proteomics; SNAP-25 protein; Synapses - metabolism; Synaptic plasticity; Synaptic transmission; Synaptosomal-Associated Protein 25 - genetics; Synaptosomal-Associated Protein 25 - metabolism; Synaptotagmin I - genetics; Synaptotagmin I - metabolism; Neuronal activity; Alzheimer’s disease; miR-128; Synaptotagmin1; SNAP-25

Alzheimer’s disease (AD) is characterized by progressive synaptic dysfunction, deterioration of neuronal transmission, and consequently neuronal death. Although there is no treatment for AD, exposure to enriched environment (EE) in mice, as well as physical and mental activity in human subjects have...