Resveratrol Prevents Tumor Growth and Metastasis by Inhibiting Lymphangiogenesis and M2 Macrophage Activation and Differentiation in Tumor-associated Macrophages

• Published in: Nutrition and cancer Vol. 68; no. 4; pp. 667 - 678
• Main Authors: Kimura, Yoshiyuki, Sumiyoshi, Maho
• Format: Journal Article
• Language: English
• Published: United States Routledge 18.05.2016; Taylor & Francis Ltd
• Subjects: Animals; Antineoplastic Agents, Phytogenic - pharmacology; Bone Neoplasms - drug therapy; Bone Neoplasms - pathology; Cell Differentiation - drug effects; Cell Line, Tumor; Cell Movement - drug effects; Chemokine CCL2 - metabolism; Growth factors; Humans; Interleukin-10 - metabolism; Lymphangiogenesis - drug effects; Macrophage Activation - drug effects; Macrophages - drug effects; Macrophages - metabolism; Macrophages - pathology; Male; Metastasis; Mice, Inbred C3H; Osteosarcoma - drug therapy; Osteosarcoma - pathology; Polyphenols; STAT3 Transcription Factor - metabolism; Stilbenes - pharmacology; Transforming Growth Factor beta1 - metabolism; Xenograft Model Antitumor Assays

Antitumor and antimetastatic effects of resveratrol on tumor-induced lymphangiogenesis through the regulation of M2 macrophages in tumor-associated macrophages currently remain unknown. Therefore, we herein examined the effects of resveratrol on M2 macrophage activation and differentiation, and thos...