Synthesis and characterization of electrically responsive poly(acrylamide)-grafted-chondroitin sulfate hydrogel for transdermal drug delivery application

• Published in: International journal of polymeric materials Vol. 69; no. 3; pp. 148 - 157
• Main Authors: Birajdar, Ravindra P., Patil, Sudha B., Alange, Vijaykumar V., Kulkarni, Raghavendra V.
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 11.02.2020; Taylor & Francis Ltd
• Subjects: Acrylamide; Chondroitin sulfate; Copolymers; Crosslinking; Drug delivery systems; electrically-responsive; Free radical polymerization; Free radicals; Glutaraldehyde; graft copolymer; Graft copolymers; Hydrogel; Hydrogels; Penetration; Polyvinyl alcohol; quetiapine fumerate; transdermal drug delivery; Transdermal medication

Electrically-responsive transdermal delivery systems (ETDS) were developed utilizing poly(acrylamide)-grafted-chondroitin sulfate (PAAm-g-CS) copolymer. A nitrogen environment based free radical polymerization was used to synthesize electrically responsive PAAm-g-CS copolymer. This PAAm-g-CS hydroge...