Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data

• Published in: Inflammation research Vol. 72; no. 5; pp. 955 - 970
• Main Authors: Tu, Bizhi, Fang, Run, Zhu, Zheng, Chen, Guang, Peng, Cheng, Ning, Rende
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2023; Springer Nature B.V
• Subjects: Allergology; Arachidonic Acid; Arthritis; Biomedical and Life Sciences; Biomedicine; Cluster analysis; Clustering; Cytochrome P450 Family 2; Cytokines; Dermatology; Diagnostic systems; Gene expression; Gene sequencing; Genes; Humans; Immune status; Immune system; Immunology; Infiltration; Inflammation; Interleukin 6; Lipid Metabolism; Lymphocytes B; Macrophages; Metabolism; Network analysis; Neurology; Original Research Paper; Osteoarthritis; Osteoarthritis - diagnosis; Osteoarthritis - genetics; Pharmacology/Toxicology; Rheumatology; Ribonucleic acid; RNA; Sequence Analysis, RNA; Synovitis; Synovium; Transcriptomes; Biomarker; Arachidonic acid; Single-cell analysis; Osteoarthritis; Immune infiltration

Background Osteoarthritis (OA) is one of degenerative-related arthritis, which can be aggravated by low-grade synovitis. It is known that arachidonic acid (AA) dysmetabolism brings OA synovitis. However, the impact of synovial AA metabolism pathway (AMP) related genes on OA remains uncovered. Method...