Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice

• Published in: Inflammation research Vol. 72; no. 6; pp. 1161 - 1173
• Main Authors: Yao, Yusheng, Lin, Daoyi, Chen, Yuzhi, Liu, Linwei, Wu, Yushang, Zheng, Xiaochun
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2023; Springer Nature B.V
• Subjects: Allergology; Animals; Apoptosis; Biomedical and Life Sciences; Biomedicine; Cognition; Cognitive ability; Cytokines; Cytokines - metabolism; Dermatology; Fluoxetine; Fluoxetine - metabolism; Fluoxetine - pharmacology; Fluoxetine - therapeutic use; Hippocampus; Immunology; Inflammation; Injection; Male; Mice; Mice, Inbred C57BL; Microglia; Microglia - metabolism; MyD88 protein; Myeloid Differentiation Factor 88 - metabolism; Neuroinflammatory Diseases; Neurology; NF-kappa B - metabolism; NF-κB protein; Original Research Paper; Pathogenesis; Pharmacology/Toxicology; Postoperative Cognitive Complications - metabolism; Pretreatment; Rheumatology; Signal Transduction; Signaling; Splenectomy; Surgery; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Neuroinflammation; Postoperative cognitive dysfunction; Fluoxetine; Toll-like receptor 4; Microglia

Objective and design Postoperative cognitive dysfunction (POCD) is a common complication following surgery among elderly patients. Emerging evidence demonstrates that neuroinflammation plays a pivotal role in the pathogenesis of POCD. This study tested the hypothesis that fluoxetine can protect agai...