Normal-subtracted preprocessing of Raman spectra aiming to discriminate skin actinic keratosis and neoplasias from benign lesions and normal skin tissues

• Published in: Lasers in medical science Vol. 35; no. 5; pp. 1141 - 1151
• Main Authors: Silveira, Landulfo, Pasqualucci, Carlos Augusto, Bodanese, Benito, Pacheco, Marcos Tadeu Tavares, Zângaro, Renato Amaro
• Format: Journal Article
• Language: English
• Published: London Springer London 01.07.2020; Springer Nature B.V
• Subjects: Accuracy; Algorithms; Basal cell carcinoma; Biochemistry; Collagen; Dentistry; Dermatitis; Diagnostic systems; Elastin; Keratosis; Lasers; Lesions; Lipids; Medical diagnosis; Medicine; Medicine & Public Health; Nucleic acids; Optical Devices; Optics; Original Article; Photonics; Quantum Optics; Raman spectra; Raman spectroscopy; Skin; Skin cancer; Skin diseases; Spectrum analysis; Squamous cell carcinoma; Subtraction; Tissues; Triolein; Spectral model; Raman spectroscopy; In vivo diagnosis; Skin neoplasia

The differences in the biochemistry of normal and cancerous tissue could be better exploited by Raman spectroscopy when the spectral information from normal tissue is subtracted from the abnormal tissues. In this study, we evaluated the use of the normal-subtracted spectra to evidence the biochemica...