Efficacy and safety of statin use in children and adolescents with familial hypercholesterolaemia: a systematic review and meta-analysis of randomized-controlled trials

• Published in: Endocrine Vol. 69; no. 2; pp. 249 - 261
• Main Authors: Anagnostis, Panagiotis, Vaitsi, Konstantina, Kleitsioti, Panagiota, Mantsiou, Chrysanthi, Pavlogiannis, Konstantinos, Athyros, Vasilios G., Mikhailidis, Dimitri P., Goulis, Dimitrios G.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2020; Springer Nature B.V
• Subjects: Adolescent; Adolescents; Apolipoprotein B; Child; Children; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical trials; Creatine; Creatine kinase; Diabetes; Endocrinology; High density lipoprotein; Humanities and Social Sciences; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hyperlipoproteinemia Type II - drug therapy; Internal Medicine; Low density lipoprotein; Medicine; Medicine & Public Health; Meta-analysis; multidisciplinary; Randomized Controlled Trials as Topic; Review; Safety; Science; Statins; Teenagers; Transaminase; Triglycerides; Systematic review; Children; Adolescents; Familial hypercholesterolaemia; Statins; Meta-analysis

Purpose Statins are the mainstay of treatment for patients with familial hypercholesterolaemia (FH). However, their efficacy and safety in children and adolescents with FH has not been well-documented. The purpose of this study was to systematically investigate and meta-analyze the best available ev...