PPARγ Regulates Macrophage Polarization by Inhibiting the JAK/STAT Pathway and Attenuates Myocardial Ischemia/Reperfusion Injury In Vivo

• Published in: Cell biochemistry and biophysics Vol. 81; no. 2; pp. 349 - 358
• Main Authors: Wang, Shengnan, Cai, Yinlian, Bu, Rongsheng, Wang, Yaoguo, Lin, Qingfan, Chen, Youfang, Wu, Chunchun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2023; Springer Nature B.V
• Subjects: Animals; Apoptosis; Apoptosis - genetics; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Biotechnology; Cardiomyocytes; Cell Biology; Enzyme-linked immunosorbent assay; Fibrosis; Genetic analysis; Glucose; Glucose - metabolism; In vivo methods and tests; Inflammation; Ischemia; Janus Kinases - metabolism; Life Sciences; Macrophages; Macrophages - metabolism; mRNA; Myocardial ischemia; Myocardial Reperfusion Injury - metabolism; Neonates; Original Paper; Oxygen; Peroxisome proliferator-activated receptors; Pharmacology/Toxicology; Polarization; PPAR gamma - genetics; PPAR gamma - metabolism; Quantitative genetics; Rats; Reperfusion; Reperfusion Injury - metabolism; Reperfusion Injury - prevention & control; Signal Transduction; STAT Transcription Factors - metabolism; Transfection; Western blotting; Myocardial fibrosis; Myocardial apoptosis; JAK/STAT pathway; Polarized macrophages; PPARγ

This study aimed to investigate the role of PPARγ and underlying mechanisms in myocardial ischemia/reperfusion injury (IRI). IRI was surgically induced in mice and neonatal rat cardiomyocytes (NRCM) were exposed to oxygen-glucose deprivation and reoxygenation (OGD/R). Quantitative genetic analysis a...