Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD
Chimeric antigen receptor (CAR) development is biased toward selecting constructs that elicit the highest magnitude of T-cell functional outputs. Here, we show that components of CAR extracellular spacer and cytoplasmic signaling domain modulate, in a cooperative manner, the magnitude of CD8(+)CTL a...
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Published in | Cancer immunology research Vol. 3; no. 4; p. 368 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.04.2015
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Subjects | |
Online Access | Get more information |
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