Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD

Chimeric antigen receptor (CAR) development is biased toward selecting constructs that elicit the highest magnitude of T-cell functional outputs. Here, we show that components of CAR extracellular spacer and cytoplasmic signaling domain modulate, in a cooperative manner, the magnitude of CD8(+)CTL a...

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Bibliographic Details
Published inCancer immunology research Vol. 3; no. 4; p. 368
Main Authors Künkele, Annette, Johnson, Adam J, Rolczynski, Lisa S, Chang, Cindy A, Hoglund, Virginia, Kelly-Spratt, Karen S, Jensen, Michael C
Format Journal Article
LanguageEnglish
Published United States 01.04.2015
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