Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD - Künkele, Annette; Johnson, Adam J; Rolczynski, Lisa S; Chang, Cindy A; Hoglund, Virginia; Kelly-Spratt, Karen S; Jensen, Michael C (Cancer immunology research, 2015)
Keywords: Animals; Brain Neoplasms - immunology; Brain Neoplasms - therapy; Cell Line, Tumor; Cytotoxicity, Immunologic - immunology; Fas Ligand Protein - immunology; fas Receptor - immunology; Genetic Vectors; Humans; Lentivirus - genetics; Lymphocyte Activation - immunology; Mice, Inbred NOD; Mice, SCID; Neuroblastoma - immunology; Neuroblastoma - therapy; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Recombinant Fusion Proteins - immunology; Signal Transduction - immunology; T-Lymphocytes, Cytotoxic - immunology; Xenograft Model Antitumor Assays