Drug delivery systems for CRISPR-based genome editors

• Published in: Nature reviews. Drug discovery Vol. 22; no. 11; pp. 875 - 894
• Main Authors: Madigan, Victoria, Zhang, Feng, Dahlman, James E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2023; Nature Publishing Group
• Subjects: 631/61/391; 639/166/985; Animals; Antigens; Biomedical and Life Sciences; Biomedicine; Biotechnology; Cancer Research; Clinical trials; CRISPR; CRISPR-Cas Systems - genetics; Drug Delivery Systems; Drugs; Gene Editing; Gene Transfer Techniques; Genes; Genetic engineering; Genome editing; Genomes; Medicinal Chemistry; Molecular Medicine; Nanoparticles; Pharmacology/Toxicology; Proteins; Proteins - genetics; Review Article; RNA polymerase; Viruses

CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however, these drugs must enter the desired cell without eliciting an unwanted immune response, so a delivery system is often required. Here, we review drug delivery systems for CRISPR-based genome editors, focusing on...